Yamane Y, Nakamura Y, Isomura M
Laboratory of Molecular Medicine, University of Tokyo, Japan.
Jpn J Hum Genet. 1997 Dec;42(4):533-7. doi: 10.1007/BF02767030.
To establish a genotypic database for dinucleotide repeat marker loci in the Japanese population, we determined allelic frequencies of 12 such markers on chromosome 13 and compared them with data from Caucasians in the GDB archive. The average heterozygosity (79%) for the 12 loci was the same for the two populations. However, allelic distributions at two of the marker loci were quite different. These data will be useful for disease studies in the Japanese population that involve linkage or sibship-pair analyses, or association studies.
为建立日本人群中二核苷酸重复标记位点的基因型数据库，我们测定了13号染色体上12个此类标记的等位基因频率，并将其与GDB档案库中高加索人的数据进行比较。两个群体中这12个位点的平均杂合度（79%）相同。然而，其中两个标记位点的等位基因分布却有很大差异。这些数据将有助于日本人群中涉及连锁分析、同胞对分析或关联研究的疾病研究。
