Fulco R A, Petix M, Salimbeni V, Torre E A
Istituto di Oncologia, Università degli Studi, Messina.
Minerva Med. 1998 Jan-Feb;89(1-2):5-10.
The evaluation of prognostic factors for breast cancers is important for therapeutic decisions both at the time of surgery and during postoperative surveillance. Cathepsin-D (cath-D) is an estrogen inducible aspartyl protease. Studies have demonstrated two biological activities, at an acidic PH, of the protein: a mitogenic and a proteolytic activity; both the growth promoting activity and the extracellular proteolytic activity suggest that cathepsin D (cath-D) may have prognostic significance in breast cancer. Measurement of cath-D in breast tissue, in fact, is highly significant in predicting recurrence as well as disease free interval and overall survival. The pS2 is a small cysteine-rich protein specifically expressed under estrogen transcriptional control. Expression of the pS2 protein in breast carcinoma is a useful guide to prognosis and response to tamoxifen: appropriate adjuvant therapy can be selected on the pS2 status of the tumor; patients with pS2 expression had better overall survival and a longer survival time after the first recurrence than those without pS2 expression. For these reasons, these two new prognostic markers could be suggested as habit factors in breast cancer.
评估乳腺癌的预后因素对于手术时的治疗决策以及术后监测都很重要。组织蛋白酶D（组织蛋白酶D）是一种雌激素诱导的天冬氨酸蛋白酶。研究表明，该蛋白在酸性pH值下具有两种生物学活性：促有丝分裂活性和蛋白水解活性；生长促进活性和细胞外蛋白水解活性均表明组织蛋白酶D（组织蛋白酶D）可能在乳腺癌中具有预后意义。事实上，测量乳腺组织中的组织蛋白酶D在预测复发以及无病生存期和总生存期方面具有高度显著性。pS2是一种富含半胱氨酸的小蛋白，在雌激素转录控制下特异性表达。pS2蛋白在乳腺癌中的表达是预后和对他莫昔芬反应的有用指导：可以根据肿瘤的pS2状态选择合适的辅助治疗；与无pS2表达的患者相比，有pS2表达的患者总生存期更好，首次复发后的生存时间更长。基于这些原因，这两种新的预后标志物可被建议作为乳腺癌的习惯因素。
