转化生长因子β信号通路中的Mads和Smads蛋白

Mads and Smads in TGF beta signalling.

作者信息

Attisano L, Wrana J L

机构信息

Department of Anatomy and Cell Biology, University of Toronto, Ontario, Canada.

出版信息

Curr Opin Cell Biol. 1998 Apr;10(2):188-94. doi: 10.1016/s0955-0674(98)80141-5.

DOI:10.1016/s0955-0674(98)80141-5

PMID:9561843

Abstract

The discovery of the Mothers against dpp (Mad) gene in Drosophila has opened a window on an entirely unique signalling pathway that functions to mediate responses to the tumour growth factor beta (TGF beta) superfamily. This pathway, which is comprised of a family of proteins related to Mad, acts to convey signals directly from TGF beta receptors to the nucleus and is implicated in the pathogenesis of human diseases.

摘要

在果蝇中发现的抗dpp（Mad）基因，为一条完全独特的信号通路打开了一扇窗，该信号通路负责介导对肿瘤生长因子β（TGFβ）超家族的反应。这条由与Mad相关的蛋白质家族组成的信号通路，直接将信号从TGFβ受体传递至细胞核，并且与人类疾病的发病机制有关。