Downward J
Imperial Cancer Research Fund, London, UK.
Curr Opin Cell Biol. 1998 Apr;10(2):262-7. doi: 10.1016/s0955-0674(98)80149-x.
Protein kinase B (PKB)/Akt is a growth-factor-regulated serine/threonine kinase which contains a pleckstrin homology domain. Binding of phosphoinositide 3-OH kinase products to the pleckstrin homology domain results in translocation of PKB/Akt to the plasma membrane where it is activated by phosphorylation by upstream kinases including the phosphoinoside-dependent kinase 1 (PDK1). Activated PKB/Akt provides a survival signal that protects cells from apoptosis induced by various stresses, and also mediates a number of metabolic effects of insulin.
蛋白激酶B（PKB）/Akt是一种受生长因子调节的丝氨酸/苏氨酸激酶，含有一个普列克底物蛋白同源结构域。磷酸肌醇3-羟基激酶产物与普列克底物蛋白同源结构域的结合导致PKB/Akt转位至质膜，在质膜上它被包括磷酸肌醇依赖性激酶1（PDK1）在内的上游激酶磷酸化而激活。活化的PKB/Akt提供一种存活信号，保护细胞免受各种应激诱导的凋亡，并且还介导胰岛素的许多代谢效应。
