Ireton K, Cossart P
Unité des Interactions Bactéries-Cellules, Institut Pasteur, Paris, France.
Curr Opin Cell Biol. 1998 Apr;10(2):276-83. doi: 10.1016/s0955-0674(98)80151-8.
Many bacterial pathogens exploit mammalian cell functions in order to promote their adherence to or uptake by host cells. Recent work has led to the identification of some of the bacterial and mammalian proteins involved in these processes. Although specific mechanisms differ among pathogens, a common aspect appears to be regulation of signaling pathways that control the actin cytoskeleton.
许多细菌病原体利用哺乳动物细胞功能来促进它们对宿主细胞的黏附或被宿主细胞摄取。最近的研究已确定了一些参与这些过程的细菌和哺乳动物蛋白质。尽管不同病原体的具体机制有所不同，但一个共同的方面似乎是对控制肌动蛋白细胞骨架的信号通路的调节。
