人房水中血清素水平的评估。
Evaluation of serotonin levels in human aqueous humor.
作者信息
Veglio F, De Sanctis U, Schiavone D, Cavallone S, Mulatero P, Grignolo F M, Chiandussi L
机构信息
Department of Medicine and Experimental Oncology, University of Turin, Torino, Italy.
出版信息
Ophthalmologica. 1998;212(3):160-3. doi: 10.1159/000027268.
PURPOSE
Serotonin is biochemically present in the iris and ciliary body of animals and humans. Controversial findings are reported about the concentrations of serotonin in aqueous humor with respect to plasma in humans. The aim of this study was to evaluate the levels of serotonin both in aqueous humor and plasma in human subjects.
METHODS
In 50 patients with glaucoma or cataract, plasma and aqueous humor serotonin levels were measured by HPLC with electrochemical detection. Serotonin plasma levels were also measured in 25 healthy subjects as controls.
RESULTS
In all patients with cataract or glaucoma, the aqueous humor serotonin concentration is significantly lower than that in plasma [1.14+/-0.29 (SEM) vs. 5.33+/-1.03 ng/ml, p<0.01]. Furthermore, in the same patients and in 25 healthy controls, serotonin plasma levels were similar.
CONCLUSION
Our study shows that serotonin is present in human aqueous humor and its concentration is 4 times lower than in plasma.
目的
血清素在动物和人类的虹膜及睫状体中存在生化特性。关于人类房水中血清素相对于血浆的浓度，有相互矛盾的研究结果报道。本研究的目的是评估人类受试者房水和血浆中血清素的水平。
方法
对50例青光眼或白内障患者，采用高效液相色谱电化学检测法测量血浆和房水中血清素水平。还对25名健康受试者的血清素血浆水平进行了测量作为对照。
结果
在所有白内障或青光眼患者中，房水中血清素浓度显著低于血浆[1.14±0.29（标准误）对5.33±1.03纳克/毫升，p<0.01]。此外，在同一批患者以及25名健康对照中，血清素血浆水平相似。
结论
我们的研究表明，血清素存在于人类房水中，其浓度比血浆中低4倍。
Zotero 插件