Kastner D L
National Institutes of Health, Bethesda, Md., USA.
Hosp Pract (1995). 1998 Apr 15;33(4):131-4, 139-40, 143-6 passim. doi: 10.3810/hp.1998.04.90.
When a patient complains of episodic fever accompanied by unexplained arthritis, peritonitis, pleurisy, or skin rash, this disorder should be considered. The disease-related gene codes for a protein that guides a neutrophil's participation in inflammation; the protein's existence implies an entire regulatory pathway hitherto unknown. At least two other mendelian periodic fever syndromes have also been described.
当患者主诉有间歇性发热并伴有不明原因的关节炎、腹膜炎、胸膜炎或皮疹时，应考虑这种疾病。该疾病相关基因编码一种指导中性粒细胞参与炎症反应的蛋白质；这种蛋白质的存在意味着存在一条迄今未知的完整调控途径。至少还有另外两种孟德尔周期性发热综合征也已被描述。
