Noldus J, Graefen M, Hammerer P, Henke R P, Huland H
Urologische Universitätsklinik Hamburg-Eppendorf.
Urologe A. 1998 Mar;37(2):195-8. doi: 10.1007/s001200050173.
Four hundred and eighty-eight radical retropubic prostatectomies (RRP) were performed on clinically localized prostate cancer at one institution within 5 years (1992-1996). These were then analyzed regarding the migration of pathological tumor stages towards more localized stages. Within the observation period, the annual rate of RRP increased by 81% from 69 to 125 cases. The authors noted a decline in the occurrence of advanced tumor stages (65.0% to 39.2%) and small cancers (< 0.5 cc: 7.2% to 1.6%) and an increase in pathological T2 tumors (30.4% to 55.2%). The rate of positive surgical margins declined from 34.7% to 12.8% (for all pathological stages). These data confirm trends which were observed in the USA with increasing detection and treatment of localized prostate cancer.
在5年时间里（1992 - 1996年），一家机构对临床局限性前列腺癌患者进行了488例耻骨后根治性前列腺切除术（RRP）。随后对这些病例进行分析，以研究病理肿瘤分期向更局限阶段的转变情况。在观察期内，RRP的年手术率从69例增加到125例，增幅达81%。作者注意到晚期肿瘤分期的发生率有所下降（从65.0%降至39.2%），小癌症（<0.5立方厘米：从7.2%降至1.6%）的发生率下降，而病理T2期肿瘤的发生率有所上升（从30.4%升至55.2%）。手术切缘阳性率从34.7%降至12.8%（所有病理分期）。这些数据证实了在美国观察到的随着局限性前列腺癌检测和治疗增加的趋势。
