Doerr P, Pirke K M
J Clin Endocrinol Metab. 1976 Sep;43(3):622-9. doi: 10.1210/jcem-43-3-622.
The response of plasma testosterone, LH and FSH to oral administration of cortisol or dexamethasone was studied for 26 h in 6 groups of 12 normal adult males. Twenty-four hour treatment with cortisol (60 mg at 1000 h, followed by 30 mg at 2 h intervals) or with dexamethasone (6 mg at 1000 h, followed by 3 mg at 6 h intervals) was without effect on testosterone during the day but suppressed the nocturnal rise completely. LH and FSH did not decrease at any time during the day and showed a highly significant increase during the second part of the night. Short-term treatment (1000-1600 h, 1600-2200 h or 2400 h-0800 h) with cortisol was less effective in suppressing the nocturnal rise in testosterone. It was concluded that administration of cortisol leading to plasma levels as seen under treatment with ACTH suppresses testosterone by abolishing or flattening the nocturnal rise. This effect was not mediated by changes in LH or FSH. Our data suggest that the ACTH-induced suppression of testosterone is due to an action of cortisol.
对6组共12名正常成年男性进行了26小时的研究，观察口服皮质醇或地塞米松后血浆睾酮、促黄体生成素（LH）和促卵泡生成素（FSH）的反应。皮质醇（1000时给予60毫克，随后每隔2小时给予30毫克）或地塞米松（1000时给予6毫克，随后每隔6小时给予3毫克）进行24小时治疗，白天对睾酮无影响，但完全抑制了夜间升高。LH和FSH在白天任何时候都没有下降，并且在夜间后半段显著升高。皮质醇短期治疗（1000 - 1600时、1600 - 2200时或2400时 - 0800时）对抑制睾酮夜间升高的效果较差。得出的结论是，给予皮质醇使血浆水平达到促肾上腺皮质激素（ACTH）治疗时所见水平，通过消除或拉平夜间升高来抑制睾酮。这种作用不是由LH或FSH的变化介导的。我们的数据表明，ACTH诱导的睾酮抑制是由于皮质醇的作用。
