Mai K T, Yazdi H M, Perkins D G, Parks W
Department of Laboratory Medicine, Ottawa Civic Hospital, University of Ottawa, Ontario, Canada.
Hum Pathol. 1998 Apr;29(4):319-22. doi: 10.1016/s0046-8177(98)90110-1.
Among 18 cases of endometriosis involving ovaries and fallopian tubes, we identified three cases with foci of endometriosis adjacent to the embryonic duct remnants in the fallopian tube. The serial sections of the blocks of tissue containing areas of interest showed segments of embryonic duct remnants with changes suggestive of gradual transformation to endometrial glands. The early changes consisted of replacement of the muscular coat surrounding the epithelium of embryonic duct remnants by the endometrial stroma with positive immunoreactivities for estrogen receptor. Subsequently there were changes of the embryonic duct remnant epithelium into endometrial epithelium with diffuse immunoreactivities for estrogen receptor. The significance of this transformation as a mechanism of development of endometriosis is discussed.
在18例累及卵巢和输卵管的子宫内膜异位症病例中，我们发现3例输卵管内子宫内膜异位灶毗邻胚胎管残余物。包含感兴趣区域的组织块连续切片显示，胚胎管残余物节段呈现出逐渐转变为子宫内膜腺体的改变。早期改变包括胚胎管残余物上皮周围的肌层被对雌激素受体呈阳性免疫反应的子宫内膜间质所取代。随后，胚胎管残余物上皮转变为对雌激素受体呈弥漫性免疫反应的子宫内膜上皮。本文讨论了这种转变作为子宫内膜异位症发生机制的意义。
