Webb S A, Roberts B, Breheny F X, Golledge C L, Cameron P D, van Heerden P V
Department of Intensive Care, Sir Charles Gairdner Hospital, Perth, Western Australia.
Anaesth Intensive Care. 1998 Apr;26(2):162-4. doi: 10.1177/0310057X9802600205.
Epidemics of bacteraemia and wound infection have been associated with the infusion of bacterially contaminated propofol administered during anaesthesia. We conducted an observational study to determine the incidence and clinical significance of administration of potentially contaminated propofol to patients in an ICU setting. One hundred patients received a total of 302 infusions of propofol. Eighteen episodes of possible contamination of propofol syringes were identified, but in all cases contamination was by a low-grade virulence pathogen. There were no episodes of clinical infection or colonization which could be attributed to the administration of contaminated propofol. During the routine use of propofol to provide sedation in ICU patients the risk of nosocomial infection secondary to contamination of propofol is extremely low.
菌血症和伤口感染的流行与麻醉期间输注受细菌污染的丙泊酚有关。我们进行了一项观察性研究，以确定在重症监护病房（ICU）环境中给患者使用潜在污染丙泊酚的发生率和临床意义。100名患者共接受了302次丙泊酚输注。发现了18起丙泊酚注射器可能被污染的事件，但在所有病例中，污染均由低毒力病原体引起。没有可归因于使用受污染丙泊酚的临床感染或定植事件。在ICU患者常规使用丙泊酚进行镇静期间，丙泊酚污染继发医院感染的风险极低。
