Richards J G, Saura J, Luque J M, Cesura A M, Gottowik J, Malherbe P, Borroni E, Gray J
Pharmaceuticals Division, F. Hoffmann-La Roche Ltd, Basel, Switzerland.
J Neural Transm Suppl. 1998;52:173-87. doi: 10.1007/978-3-7091-6499-0_17.
The present report reviews recent advances in mapping the cellular sites of synthesis and catalytic activity, as well as age- and disease-related changes of monoamine oxidases A and B in the brain. A transgenic model of oxidative stress is also described. The relevance of these findings for the physiological and pathophysiological roles of monoamine oxidases is briefly discussed.
