大鼠肝脏中两种形式的单胺氧化酶对多巴胺和去甲肾上腺素的氧化作用。

The oxidation of dopamine and epinine by the two forms of monoamine oxidase from rat liver.

作者信息

Strolin Benedetti M, Sanson G, Bona L, Gallina M, Persiani S, Tipton K F

机构信息

Department of Preclinical Development and Human Pharmacology, Zambon Group, Bresso, Italy.

出版信息

J Neural Transm Suppl. 1998;52:233-8. doi: 10.1007/978-3-7091-6499-0_22.

DOI:10.1007/978-3-7091-6499-0_22

PMID:9564622

Abstract

Information on the "in vitro" oxidation of epinine by monoamine oxidase (MAO) compared to dopamine is very poor. The aim of this work was to study the oxidative deamination of epinine and dopamine by rat liver MAO-A and MAO-B. The contributions of MAO-A and B to the metabolism of dopamine (55% and 45%, respectively) and epinine (70% and 30%, respectively) were similar. The results of this study show that epinine is a substrate for both forms of MAO in rat liver, although the contribution of MAO A to the deamination of this secondary amine appears to be slightly more important than that of MAO B.

摘要

与多巴胺相比，关于肾上腺素在单胺氧化酶（MAO）作用下的“体外”氧化的信息非常匮乏。这项工作的目的是研究大鼠肝脏MAO - A和MAO - B对肾上腺素和多巴胺的氧化脱氨基作用。MAO - A和MAO - B对多巴胺代谢的贡献（分别为55%和45%）以及对肾上腺素代谢的贡献（分别为70%和30%）相似。这项研究结果表明，肾上腺素是大鼠肝脏中两种形式MAO的底物，尽管MAO A对这种仲胺脱氨基作用的贡献似乎比MAO B略为重要。