Comparative effects of GnRH agonist therapy. Review of clinical studies and their implications.

OBJECTIVE

To understand why differences in gonadotropin releasing hormone (GnRH) agonist therapeutic protocols may affect their efficacy and safety profiles, to understand the important study design facets regarding the literature on GnRH agonist treatment of endometriosis and to compare the efficacy and side effect profiles of FDA-approved GnRH agonist therapies used for the management of endometriosis and consider the implications.

STUDY DESIGN

Review of the English-language literature regarding the use of GnRH agonists for the management of endometriosis.

RESULTS

A limited number of studies are available that directly compare the effects of different GnRH agonists. However, contrary to medical opinion, it appears that there are significant differences between GnRH agonist therapies.

CONCLUSION

The data suggest that it may be possible to reduce doses or alter regimens of GnRH agonists so as to reduce side effects while maintaining efficacy.