Haneda T, Ido A, Fujikane T, Tanaka H, Tanazawa S, Morimoto H, Kato J, Kanaya K, Honda H, Sakai H, Akita N, Hirayama T, Onodera S, Kikuchi K
First Department of Internal Medicine, Asahikawa Medical College.
Nihon Ronen Igakkai Zasshi. 1998 Jan;35(1):33-8. doi: 10.3143/geriatrics.35.33.
The present study investigated the effect of bisoprolol, a beta 1-selective beta-blocker without intrinsic sympathomimetic activity (ISA), on lipid and glucose metabolism and quality of life (QOL) in elderly patients with essential hypertention. Bisoprolol at doses of 5-10 mg was administered once daily for 12 weeks to 60 non-elderly and 21 elderly outpatients with mild to moderate essential hypertension. In both groups bisoprolol significantly decreased both systolic and diastolic blood pressures and significantly reduced pulse rates to the same extent. The levels of serum cholesterol, HDL-cholesterol and triglyceride, and the response of plasma glucose and insulin to 75 g oral glucose load, were not changed in either group by the bisoprolol treatment. Bisoprolol significantly improved QOL in both groups. Bradycardia, a side effect attributable to bisoprolol, was noted in only one patient in the elderly group. These results suggest that bisoprolol is a safe and useful antihypertensive drug in elderly and non-elderly patients with essential hypertension.
本研究调查了比索洛尔（一种无内在拟交感活性的β1选择性β受体阻滞剂）对老年原发性高血压患者脂质和葡萄糖代谢以及生活质量（QOL）的影响。对60例非老年和21例老年轻至中度原发性高血压门诊患者，每日一次给予5 - 10mg比索洛尔，持续12周。两组中，比索洛尔均显著降低收缩压和舒张压，并在相同程度上显著降低脉搏率。比索洛尔治疗后，两组的血清胆固醇、高密度脂蛋白胆固醇和甘油三酯水平，以及血浆葡萄糖和胰岛素对75g口服葡萄糖负荷的反应均未改变。比索洛尔显著改善了两组的生活质量。老年组仅1例患者出现了归因于比索洛尔的副作用——心动过缓。这些结果表明，比索洛尔对老年和非老年原发性高血压患者是一种安全有效的抗高血压药物。
