Lyle W A, Jin G J
The Eye Institute of Utah, Salt Lake City 84107, USA.
Arch Ophthalmol. 1998 Apr;116(4):425-8. doi: 10.1001/archopht.116.4.425.
To examine the long-term safety and efficacy of hyperopic automated lamellar keratoplasty (H-ALK) for correction of primary hyperopia and for consecutive hyperopia following overcorrected myopic refractive surgery.
A prospective study was done on 67 eyes of 50 consecutive patients who underwent H-ALK between March 17, 1993, and August 18, 1995. Hyperopic automated lamellar keratoplasty was performed for primary hyperopia in 25 eyes (group 1) and for consecutive hyperopia after myopic refractive surgery in 42 eyes (group 2, radial keratotomy, 41 eyes, and myopic automated lamellar keratoplasty, 1 eye). The eyes were followed up for a mean+/-SD of 19.2+/-12.8 months (range, 3-49 months), 58 (87%) of them with 6 months' follow-up, and 45 (67%) of them with at least 1 year's follow-up. Twenty-one eyes were followed up for 2 to 4 years.
The overall mean+/-SD preoperative spherical equivalent was +2.87+/-1.28 diopters (D). The mean+/-SD postoperative spherical equivalent was -0.03+/-1.42 D at 3 months, -0.42+/-2.25 D at 6 months, -0.55+/-3.00 D at 1 year, -1.58+/-1.53 D at 2 years, and -0.35+/-1.79 D at the last follow-up. A mean myopic shift of 0.50 D was noted between 3 months and 1 year, and of 1.00 D between 1 and 2 years. Hyperopia was meaningfully reduced and visual acuity was improved by H-ALK, especially for patients with primary hyperopia. Long-term refractive instability, however, is a serious problem with this procedure. In this series, 11 (26%) of 42 eyes in which H-ALK was performed for consecutive hyperopia developed iatrogenic keratoconus.
Based on this study, the long-term instability of H-ALK and the high incidence of iatrogenic keratoconus following the procedure should discourage its use, especially for consecutive hyperopia following radial keratotomy.
探讨远视性自动板层角膜成形术(H-ALK)矫正原发性远视及近视屈光手术过矫后所致继发性远视的长期安全性和有效性。
对1993年3月17日至1995年8月18日期间连续50例患者的67只眼进行前瞻性研究。其中25只眼(第1组)因原发性远视接受H-ALK手术,42只眼(第2组)因近视屈光手术后的继发性远视接受该手术(放射状角膜切开术41只眼,近视性自动板层角膜成形术1只眼)。随访时间平均为19.2±12.8个月(范围3 - 49个月),其中58只眼(87%)随访6个月,45只眼(67%)随访至少1年。21只眼随访2至4年。
术前总体平均±标准差球镜等效度为+2.87±1.28屈光度(D)。术后3个月时平均±标准差球镜等效度为-0.03±1.42 D,6个月时为-0.42±2.25 D,1年时为-0.55±3.00 D,2年时为-1.58±1.53 D,末次随访时为-0.35±1.79 D。3个月至1年平均近视漂移0.50 D,1至2年平均近视漂移1.00 D。H-ALK可显著降低远视度数并提高视力,尤其是原发性远视患者。然而,该手术存在严重的长期屈光不稳定问题。在本研究系列中,42只因继发性远视接受H-ALK手术的眼中,有11只(26%)发生了医源性圆锥角膜。
基于本研究,H-ALK的长期不稳定性以及术后医源性圆锥角膜的高发生率,应不鼓励使用该手术,尤其是用于放射状角膜切开术后的继发性远视。