Ishii K, Hosaka N, Toki T, Momose M, Hidaka E, Tsuchiya S, Katsuyama T
Division of Clinical Pathology, Nagano Cancer Detection Centre, Matsumoto, Japan.
Virchows Arch. 1998 Apr;432(4):315-22. doi: 10.1007/s004280050172.
Adenoma malignum of the uterine cervix (mucinous type of minimal deviation adenocarcinoma, mucinous MDA), is a unique neoplasm that is difficult to diagnose owing to the deceptively benign appearance of the tumour cells. The present study was undertaken to explore the phenotypic expression of this tumour compared with those of non-neoplastic cervical tissues and of cervical carcinomas of various types. Ten cases of mucinous MDA, 50 cases with non-neoplastic cervical tissues, 13 of cervical adenocarcinoma including the mucinous (endocervical or intestinal type) and endometrioid types, and 2 of mucoepidermoid carcinoma were examined by various histochemical staining methods, including those for gastric mucins, pepsinogen, lysozyme, chromogranin A and carcinoembryonic antigen. The results revealed that mucinous MDA characteristically exhibited gastric phenotypes. The presence of gastric metaplasia was also demonstrated in 9 cases of mucinous MDA and in 5 of the other cases examined. The 7 endocervical-type adenocarcinomas also included 4 that expressed gastric phenotypes, and 2 of the 3 intestinal-type adenocarcinomas showed the same properties focally. These results indicate the presence of a group of lesions expressing gastric phenotypes in the uterine cervix and suggest a close relationship between these lesions. Cervical adenocarcinomas expressing gastric phenotypes are probably derived from MDA.
子宫颈恶性腺瘤（微小偏离腺癌黏液型，黏液性微小偏离腺癌）是一种独特的肿瘤，因其肿瘤细胞看似良性的外观而难以诊断。本研究旨在探讨该肿瘤与非肿瘤性宫颈组织及各种类型宫颈癌相比的表型表达。通过多种组织化学染色方法，包括针对胃黏液、胃蛋白酶原、溶菌酶、嗜铬粒蛋白A和癌胚抗原的染色方法，对10例黏液性微小偏离腺癌、50例非肿瘤性宫颈组织、13例宫颈腺癌（包括黏液性（宫颈内膜型或肠型）和子宫内膜样型）以及2例黏液表皮样癌进行了检查。结果显示，黏液性微小偏离腺癌具有典型的胃表型。在9例黏液性微小偏离腺癌和5例其他检查病例中也证实存在胃化生。7例宫颈内膜型腺癌中有4例表达胃表型，3例肠型腺癌中有2例局部表现出相同特征。这些结果表明子宫颈存在一组表达胃表型的病变，并提示这些病变之间存在密切关系。表达胃表型的宫颈腺癌可能起源于微小偏离腺癌。
