Kuhnen C, Tolnay E, Steinau H U, Voss B, Müller K M
Institute of Pathology, University Hospital Bergmannsheil, Bochum, Germany.
Virchows Arch. 1998 Apr;432(4):337-42. doi: 10.1007/s004280050175.
Overexpression of c-Met receptor/hepatocyte growth factor (scatter factor) system (c-Met/HGF/SF) as a physiologically paracrine cellular signaling system is thought to be involved in the progression of malignant tumours. In 26 synovial sarcomas and epithelioid sarcomas, c-Met and HGF/SF expression was analysed immunohistochemically. There were 10 biphasic synovial sarcomas, 7 of which showed moderate to strong c-Met expression in epithelial areas compared with the fibrous component, with corresponding expression of HGF/SF. Six of 9 monophasic fibrous synovial sarcomas showed only very faint c-Met and corresponding HGF/SF expression. In 7 epithelioid sarcomas strong expression of c-Met and HGF/SF was observed within epithelioid tumour cells. Non-radioactive in situ hybridization demonstrated the synthesis of c-Met receptor in tumor cells by detecting c-met-mRNA. This analysis shows that in synovial sarcomas and epithelioid sarcomas, tumour entities with epithelial and mesenchymal structures, c-Met and HGF/SF overexpression can be detected, indicating a role of this signaling system in these subtypes of sarcoma, and especially in the more epithelioid tumour phenotype. An autocrine interaction between overexpressed c-Met receptor and HGF/SF may be hypothesized.
c-Met受体/肝细胞生长因子（散射因子）系统（c-Met/HGF/SF）作为一种生理性旁分泌细胞信号系统，其过表达被认为与恶性肿瘤的进展有关。对26例滑膜肉瘤和上皮样肉瘤进行免疫组化分析，检测c-Met和HGF/SF的表达情况。其中有10例双相性滑膜肉瘤，7例上皮区域的c-Met表达中度至强于纤维成分，同时伴有相应的HGF/SF表达。9例单相性纤维性滑膜肉瘤中有6例仅显示非常微弱的c-Met及相应的HGF/SF表达。在7例上皮样肉瘤中，上皮样肿瘤细胞内观察到c-Met和HGF/SF的强表达。非放射性原位杂交通过检测c-met-mRNA证实肿瘤细胞中存在c-Met受体的合成。该分析表明，在滑膜肉瘤和上皮样肉瘤这两种具有上皮和间叶结构的肿瘤实体中，可检测到c-Met和HGF/SF的过表达，提示该信号系统在这些肉瘤亚型中发挥作用，尤其在更具上皮样的肿瘤表型中。可以推测过表达的c-Met受体与HGF/SF之间存在自分泌相互作用。
