Somatosensory evoked potentials in very preterm infants in relation to L-thyroxine supplementation.
作者信息
Smit B J, Kok J H, de Vries L S, van Wassenaer A G, Dekker F W, Ongerboer de Visser B W
机构信息
Department of Neonatology, Emma Children's Hospital AMC, University of Amsterdam, Amsterdam, The Netherlands.
出版信息
Pediatrics. 1998 May;101(5):865-9. doi: 10.1542/peds.101.5.865.
OBJECTIVE
To study the effect of L-thyroxine supplementation on neurologic maturation in very preterm infants with transient hypothyroxinemia.
DESIGN
Randomized, double-blind, placebo-controlled, L-thyroxine supplementation trial.
SETTING
Level III neonatal intensive care unit.
SUBJECTS
A total of 200 infants <30 weeks' gestational age.
INTERVENTION
Subjects were randomly assigned to receive L-thyroxine (8 microg/kg birth weight per day) or a placebo during the first 6 weeks of life.
METHODS
Median nerve somatosensory evoked potentials were recorded, measuring cortical N1 peak latency at 2 weeks of age, at term, and at 6 months (corrected) age.
RESULTS
Cortical N1 peak latency was not decreased significantly in the L-thyroxine group compared with the placebo group throughout the study period.
CONCLUSION
L-Thyroxine supplementation during the first 6 weeks of life did not decrease cortical N1 peak latency in infants of <30 weeks' gestational age.
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