Balteskard L, Unneberg K, Mjaaland M, Sager G, Jenssen T G, Revhaug A
Department of Surgery, Tromsø University Hospital, Norway.
Eur Surg Res. 1998;30(2):79-94. doi: 10.1159/000008562.
Growth hormone (GH) and insulin-like growth factor-1 (IGF-1) may be beneficial against the protein catabolism seen in injury and septicemia. Further understanding of their effects on carbohydrate metabolism is needed. In a septic porcine model receiving total parenteral nutrition, pretreatment with GH or IGF-1 (or no treatment in controls) was followed by an infusion of live Escherichia coli bacteria. Endogenous glucose production, carbohydrate oxidation, glucose and lactate fluxes over the liver, gastrointestinal organs, kidney, and hindleg were determined. Endogenous glucose production increased during septicemia in the GH group. The metabolic acidosis induced by septicemia was augmented by GH, but attenuated by IGF-1. The alanine and lactate levels were significantly higher in the GH- than in the IGF-1 treated animals during septicemia. IGF-1 pretreatment appeared to induce favorable effects while GH pretreatment might produce unfavorable effects on carbohydrate metabolism in septic piglets.
生长激素（GH）和胰岛素样生长因子-1（IGF-1）可能有助于对抗损伤和败血症中出现的蛋白质分解代谢。需要进一步了解它们对碳水化合物代谢的影响。在接受全胃肠外营养的败血症猪模型中，用GH或IGF-1进行预处理（对照组不进行处理），随后注入活的大肠杆菌。测定内源性葡萄糖生成、碳水化合物氧化、肝脏、胃肠道器官、肾脏和后肢的葡萄糖和乳酸通量。GH组败血症期间内源性葡萄糖生成增加。败血症诱导的代谢性酸中毒在GH作用下增强，但在IGF-1作用下减弱。败血症期间，GH治疗组动物的丙氨酸和乳酸水平显著高于IGF-1治疗组动物。IGF-1预处理似乎产生有利影响，而GH预处理可能对败血症仔猪的碳水化合物代谢产生不利影响。
