Chippaux J P, Boulanger D, Brémond P, Campagne G, Véra C, Sellin B
Mem Inst Oswaldo Cruz. 1997 Sep-Oct;92(5):725-8. doi: 10.1590/s0074-02761997000500030.
The Centre de Recherche sur les Méningites et les Schistosomes (CERMES) is a research institute depending on the Organisation de Coordination et de Coopération pour la lutte contre les Grandes Endémies--a West African Organization for Public Health--devoted to the studies on schistosomiasis and meningitis. The staff includes 32 persons with 11 scientists and one financial officer. The activities of the CERMES involving schistosomiasis concern three research units: (a) ecology of human and animal schistosomiasis transmission; the CERMES defined the different patterns of schistosomiasis transmission in Niger (involving African dry savana); in this field, we have shown, (i) the existence of important variability in conditions of transmission of S. haematobium and, (ii) natural hybridization between parasitic species of the ruminants (S. bovis and S. curassoni) and genetic interaction between human and animal parasites; (b) definition of morbidity indicators usable for rapid assessment methods, for appraisal of the severity of the disease and for the evaluation of the efficiency of control methods; we have established the correlation between ultrasonographic data and some cheap and simple field indicators; (c) immune response and protective immunity induced by recombinant glutathion S-transferase (Sm28, Sb28 and Sh28) in homologous and heterologous animal models including goats, sheep and non human primates (Erythrocebus patas). In Niger, we participate in all control programs against schistosomiasis to define control strategies, to supervise operations and to participate in their evaluation with external experts. International collaborations constitute a frame including four laboratories in Africa and six laboratories in developed countries (Europe and USA).
脑膜炎与血吸虫病研究中心（CERMES）是一个隶属于协调与合作抗击重大地方病组织（一个西非公共卫生组织）的研究机构，致力于血吸虫病和脑膜炎的研究。该机构员工有32人，其中包括11名科学家和1名财务官员。CERMES涉及血吸虫病的活动涉及三个研究单位：（a）人类和动物血吸虫病传播生态学；CERMES确定了尼日尔（涉及非洲干燥稀树草原）血吸虫病传播的不同模式；在这一领域，我们已经表明，（i）埃及血吸虫传播条件存在重要变异性，以及（ii）反刍动物寄生虫物种（牛血吸虫和库拉索血吸虫）之间的自然杂交以及人类和动物寄生虫之间的基因相互作用；（b）确定可用于快速评估方法、评估疾病严重程度以及评估控制方法效率的发病指标；我们已经建立了超声数据与一些廉价且简单的现场指标之间的相关性；（c）重组谷胱甘肽S-转移酶（Sm28、Sb28和Sh28）在包括山羊、绵羊和非人类灵长类动物（赤猴）在内的同源和异源动物模型中诱导的免疫反应和保护性免疫。在尼日尔，我们参与所有抗击血吸虫病的控制项目，以确定控制策略、监督行动并与外部专家一起参与评估。国际合作构成了一个框架，包括非洲的四个实验室和发达国家（欧洲和美国）的六个实验室。
