Bykhovskiĭ V Ia, Zaĭtseva N I, Eliseev A A
Bach Institute of Biochemistry, Russian Academy of Sciences, Moscow, Russia.
Prikl Biokhim Mikrobiol. 1998 Jan-Feb;34(1):3-21.
Various aspects of metabolism and biotechnology of tetrapyrroles are reviewed. Structures and properties of newly discovered tetrapyrrole pigments, biosynthesis of most important functional tetrapyrroles (hemes, chlorophylls, corrinoids, siroheme, and methanogenesis factor F430), and biotechnological methods of production of porphyrins and corrinoids are discussed. 5-Aminolevulinic acid is shown to be a promising anticancer preparation.
本文综述了四吡咯的代谢和生物技术的各个方面。讨论了新发现的四吡咯色素的结构和性质、最重要的功能性四吡咯(血红素、叶绿素、类咕啉、siroheme和产甲烷因子F430)的生物合成,以及卟啉和类咕啉的生物技术生产方法。5-氨基乙酰丙酸被证明是一种有前景的抗癌制剂。