Mobley J, Marsh J N, Hall C S, Hughes M S, Brandenburger G H, Miller J G
Department of Physics, Washington University, St. Louis, Missouri 63130-4899, USA.
J Acoust Soc Am. 1998 Apr;103(4):2145-53. doi: 10.1121/1.421360.
The phase velocities in suspensions of Albunex, an ultrasound contrast agent, are determined using the technique of broadband phase spectroscopy. In these suspensions, phase velocities were measured as a function of Albunex concentration in Isoton II (buffered saline). The dispersion over the measurement bandwidth (1-15 MHz) grew with increasing Albunex concentration, exhibiting a 221-m/s change (17% increase) in phase velocity between 1.0 and 3.8 MHz at the highest concentration reported (32 microL Albunex/8 mL Isoton). The dispersion behavior of the Albunex suspensions is described using a model of encapsulated gas bubbles. The influence of the dispersion in Albunex on broadband pulses is discussed, as well as the potential impact this dispersion may have on the formation of ultrasonic images of the heart.
使用宽带相位光谱技术测定了超声造影剂Albunex悬浮液中的相速度。在这些悬浮液中，相速度是作为Albunex在等渗II（缓冲盐水）中的浓度的函数来测量的。在测量带宽（1 - 15 MHz）上的频散随着Albunex浓度的增加而增大，在报告的最高浓度（32微升Albunex / 8毫升等渗液）下，1.0至3.8 MHz之间的相速度变化了221米/秒（增加了17%）。Albunex悬浮液的频散行为用封装气泡模型来描述。讨论了Albunex中的频散对宽带脉冲的影响，以及这种频散可能对心脏超声图像形成产生的潜在影响。
