Lee M D, Aloyo V J, Fluharty S J, Simansky K J
Department of Pharmacology, MCP-Hahnemann School of Medicine, Allegheny University of the Health Sciences, Philadelphia, PA 19129, USA.
Psychopharmacology (Berl). 1998 Apr;136(3):304-7. doi: 10.1007/s002130050570.
Unilateral infusion of the selective 5-HT1B agonist, CP-93,129 (3-(1,2,5,6-tetrahydropyrid-4-yl) pyrrolo[3,2-b]pyrid-5-one) into the parabrachial nucleus (PBN) of the pons reduced food consumption by rats. The hypophagia was dose-related (ED50 approximately 1 nmol) and associated with fewer observations of feeding and more periods of inactivity. Water intake, grooming and exploratory activity were unaffected. CP-93,129 also decreased food intake when injected into the hypothalamic paraventricular nucleus, but this action was 50-fold less potent than administration into the PBN. Autoradiography demonstrated 5-HT1B sites in the PBN; this binding was displaced by CP-93,129. The results implicate parabrachial 5-HT1B receptors in mediating serotonergic enhancement of satiation.
将选择性5-羟色胺1B受体激动剂CP-93,129（3-(1,2,5,6-四氢吡啶-4-基)吡咯并[3,2-b]吡啶-5-酮）单侧注入大鼠脑桥臂旁核（PBN）可减少大鼠的食物摄入量。这种食欲减退与剂量相关（半数有效剂量约为1纳摩尔），且与进食观察次数减少和更多的不活动期有关。水摄入量、梳理毛发和探索活动均未受影响。将CP-93,129注入下丘脑室旁核时也会减少食物摄入量，但该作用的效力比注入PBN时低50倍。放射自显影显示PBN中有5-羟色胺1B受体位点；这种结合可被CP-93,129取代。结果表明，臂旁5-羟色胺1B受体参与介导血清素能增强饱腹感的作用。
