Michet C
Mayo Clinic, Rochester, MN 55905, USA.
Curr Opin Rheumatol. 1998 Mar;10(2):129-35. doi: 10.1097/00002281-199803000-00008.
The epidemiology of early synovitis syndromes in the community remains of interest. Attempts to identify those cases likely to progress to erosive rheumatoid arthritis have yielded some prognostic features that may be clinically applicable. The incidence of juvenile rheumatoid arthritis appears to fluctuate in a cyclic pattern, suggesting microbial or other environmental factors contributing to its occurrence. In the United States, the frequency of scleroderma varies among racial groups with rising rates noted especially among African-American women. A very high prevalence of scleroderma among Oklahoma Choctaws is providing an opportunity to study interactions of environmental and genetic risk factors. Excess weight in middle-aged women and possibly low intake of antioxidants contribute to the progression of established osteoarthritis of the knee.
社区中早期滑膜炎综合征的流行病学仍备受关注。识别那些可能进展为侵蚀性类风湿关节炎的病例的尝试已产生了一些可能具有临床应用价值的预后特征。青少年类风湿关节炎的发病率似乎呈周期性波动，这表明微生物或其他环境因素对其发病有影响。在美国，硬皮病的发病率在不同种族群体中有所不同，尤其是非裔美国女性的发病率呈上升趋势。俄克拉荷马州乔克托族人中硬皮病的患病率非常高，这为研究环境和遗传风险因素的相互作用提供了机会。中年女性体重超标以及可能的抗氧化剂摄入量低会促使已有的膝关节骨关节炎病情进展。
