Guzmán-Rojas L, Alcocer-González J M, Madrid-Marina V
División de Virología Molecular, Centro de Investigación sobre Enfermedades Infecciosas, Instituto Nacional de Salud Pública, México.
Salud Publica Mex. 1998 Jan-Feb;40(1):38-46.
Cervical cancer represents a severe public health problem and has been associated to the presence of human papillomavirus. Strategies are presently being tested which target the virus to attempt to control disease progress. Studies on the humoral and cell-mediated immunity of the papillomavirus infection have been useful in the development of a vaccine. Synthetic virus-like particles have been validated as vaccine against several animal papillomaviruses and used to map the seroepidemiology of the human papillomavirus infection, and define neutralizing antibodies. Induction of cell-mediated immunity to HPV early proteins is bound to become a therapeutic approach to HPV infections. Recent advances have centered on directing the immune response to prevent infection, to virus-infected cells and to virally transformed cells, with favourable results.
宫颈癌是一个严重的公共卫生问题，且与人乳头瘤病毒的存在有关。目前正在测试针对该病毒的策略，试图控制疾病进展。对乳头瘤病毒感染的体液免疫和细胞介导免疫的研究，在疫苗开发中发挥了作用。合成病毒样颗粒已被验证可作为针对多种动物乳头瘤病毒的疫苗，并用于绘制人乳头瘤病毒感染的血清流行病学图谱，以及确定中和抗体。诱导针对人乳头瘤病毒早期蛋白的细胞介导免疫必将成为治疗人乳头瘤病毒感染的一种方法。最近的进展集中在引导免疫反应以预防感染、针对病毒感染细胞和病毒转化细胞，取得了良好效果。
