约氏疟原虫感染及乙胺嘧啶治疗小鼠过程中尿素及相关酶的状态

Status of urea and related enzymes during Plasmodium yoelii infection and pyrimethamine treatment in mice.

作者信息

Agrawal A, Tripathi L M, Pandey V C

机构信息

Department of Biochemistry, Central Drug Research Institute, Lucknow, India.

出版信息

Indian J Exp Biol. 1997 Nov;35(11):1194-7.

Abstract

Plasmodium yoelii infection alters the hepatic levels of key enzymes of urea cycle, viz.carbamoyl phosphates synthetase (EC 6.3.4.16) and ornithine transcarbamoylase (EC 2.1.3.3) and urea levels in mice. The urea level was found elevated in liver, brain and plasma during P. yoelii infection. However, carbamoyl phosphate synthetase and ornithine transcarbamoylase were noticeably decreased during P. yoelii infection. Pyrimethamine treatment (10 mg/kg body weight for 4 days) brought back the altered parameters to normal a week after cessation of drug treatment.

摘要

约氏疟原虫感染会改变小鼠肝脏中尿素循环关键酶的水平，即氨甲酰磷酸合成酶（EC 6.3.4.16）和鸟氨酸转氨甲酰酶（EC 2.1.3.3）以及尿素水平。在约氏疟原虫感染期间，肝脏、大脑和血浆中的尿素水平升高。然而，在约氏疟原虫感染期间，氨甲酰磷酸合成酶和鸟氨酸转氨甲酰酶显著降低。乙胺嘧啶治疗（10毫克/千克体重，持续4天）在停药一周后使改变的参数恢复正常。

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