Singh Y, Jaiswal A K, Singh M, Bhattacharya S K
Department of Anatomy & Pharmacology, Banaras Hindu University, Varanasi, India.
Indian J Exp Biol. 1997 Dec;35(12):1284-90.
Haloperidol (0.1 mg/kg, i.p.) treatment was given from day 12 to 20 of gestation to pregnant rats, this being the critical period for neural development in this species. The pups born were subjected to open-field exploratory behaviour, tunnel-board exploratory behaviour, elevated zero-maze and elevated plus maze behaviour tests at 7-8 weeks of age. The results indicate that prenatal haloperidol treatment induces a significant increase in open-field ambulations and rearings, decrease in scratching and licking/washing behaviours whereas grooming and faecal droppings remain unchanged. Significantly reduced activity in the centre and increased activity in the periphery of the tunnel board was noted. These suggest presence of anxiety in these animals. Significant anxiogenic behavioural patterns were also observed on elevated zero-maze and plus-maze in the prenatally haloperidol treated offsprings. The results suggest that prenatal exposure of haloperidol leaves a lasting effect on offsprings resulting in hyper-emotional responsiveness and anxiety state.
在妊娠第12天至20天给怀孕大鼠腹腔注射氟哌啶醇（0.1毫克/千克），此为该物种神经发育的关键时期。出生的幼崽在7至8周龄时接受旷场探索行为、隧道板探索行为、高架零迷宫和高架十字迷宫行为测试。结果表明，产前氟哌啶醇治疗可使旷场中的行走和竖尾显著增加，抓挠和舔舐/梳理行为减少，而理毛和粪便排泄保持不变。注意到隧道板中央的活动显著减少，周边的活动增加。这些表明这些动物存在焦虑。在产前接受氟哌啶醇治疗的后代的高架零迷宫和十字迷宫中也观察到显著的致焦虑行为模式。结果表明，产前接触氟哌啶醇会对后代产生持久影响，导致过度情绪反应和焦虑状态。
