Sterniste W, Gabriel C, Sacher M
Pediatric Department, Danube Hospital, Vienna, Austria.
Pediatr Cardiol. 1998 May-Jun;19(3):256-8. doi: 10.1007/s002469900299.
Many studies demonstrate the efficacy of closure of a patent ductus arteriosus with indomethacin, but also show that success diminishes markedly with increasing postnatal age. For this reason surgical ligation is usually preferred after the first month of life. We describe the case of a male premature infant (25 weeks gestation, birth weight 680 g), in whom a PDA was successfully closed with indomethacin (0.1 mg/kg once daily intravenously for 6 days) at the age of 11 weeks. Thus it may be concluded that closure by drug may be attempted before surgical ligation even in cases of advanced postnatal age.
许多研究证实了使用吲哚美辛关闭动脉导管未闭的疗效，但也表明随着出生后年龄的增加，成功率会显著降低。因此，通常在出生后第一个月后首选手术结扎。我们描述了一名男性早产儿（妊娠25周，出生体重680克）的病例，该患儿在11周龄时使用吲哚美辛（0.1毫克/千克，每日静脉注射一次，共6天）成功关闭了动脉导管未闭。因此，可以得出结论，即使在出生后年龄较大的情况下，也可以在手术结扎前尝试药物关闭。
