2-氟甲基苯并吡喃钾通道开放剂的合成及其血管舒张活性
Synthesis and vasorelaxant activity of 2-fluoromethylbenzopyran potassium channel openers.
作者信息
Takahashi T, Koga H, Sato H, Ishizawa T, Taka N, Imagawa J
机构信息
Fuji-gotemba Research Laboratories, Chugai Pharmaceutical Co., Ltd., Shizuoka, Japan.
出版信息
Bioorg Med Chem. 1998 Mar;6(3):323-37. doi: 10.1016/s0968-0896(97)10035-9.
PMID:9568286
Abstract
The synthesis and vasorelaxant activity of 2-fluoromethylbenzopyran potassium channel openers are described. These (2-fluoromethyl) derivatives displayed smooth muscle relaxant activities comparable to or more potent than the corresponding 2-methyl analogues.
摘要
描述了2-氟甲基苯并吡喃钾通道开放剂的合成及其血管舒张活性。这些（2-氟甲基）衍生物表现出与相应的2-甲基类似物相当或更强的平滑肌舒张活性。
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