大豆、牛碱性胰蛋白酶和牛初乳胰蛋白酶抑制剂对大鼠和牛胰蛋白酶及胰凝乳蛋白酶的抑制作用。
Inhibition of rat and bovine trypsins and chymotrypsins by soybean, bovine basic pancreatic, and bovine colostrum trypsin inhibitors.
作者信息
Esparza I, Brock J H
机构信息
Fundación F. Cuenca Villoro, Instituto de Bioquímica y Nutrición D. Juan Carlos I, Zaragoza, Spain.
出版信息
Comp Biochem Physiol B. 1978;61(3):347-50. doi: 10.1016/0305-0491(78)90135-9.
PMID:95686
Abstract
- Bovine (Bos taurus) trypsin and trypsin activity in rat (Rattus norvegicus) pancreatic extract were inhibited by soybean trypsin inhibitor and by bovine basic pancreatic and colostrum inhibitors. 2. Bovine alpha-chymotrypsin was inhibited by soybean and bovine basic pancreatic inhibitors but only weakly by colostrum inhibitor. 3. Chymotrypsin activity in rat pancreatic extract was due to at least three different components against all of which the inhibitors were largely ineffective. 4. It is concluded that bovine colostrum inhibitor has a more limited inhibition spectrum than the phylogenetically related basic pancreatic inhibitor which, in turn, is less active against rat than against bovine enzymes.
摘要
- 大豆胰蛋白酶抑制剂、牛碱性胰蛋白酶抑制剂和初乳抑制剂可抑制牛（Bos taurus）胰蛋白酶以及大鼠（Rattus norvegicus）胰腺提取物中的胰蛋白酶活性。2. 大豆和牛碱性胰蛋白酶抑制剂可抑制牛α-糜蛋白酶，但初乳抑制剂对其抑制作用较弱。3. 大鼠胰腺提取物中的糜蛋白酶活性至少由三种不同成分引起，而这些抑制剂对所有这些成分的抑制作用大多无效。4. 得出的结论是，牛初乳抑制剂的抑制谱比系统发育相关的碱性胰蛋白酶抑制剂更有限，而碱性胰蛋白酶抑制剂对大鼠酶的活性比对牛酶的活性更低。
相似文献
1
Inhibition of rat and bovine trypsins and chymotrypsins by soybean, bovine basic pancreatic, and bovine colostrum trypsin inhibitors.大豆、牛碱性胰蛋白酶和牛初乳胰蛋白酶抑制剂对大鼠和牛胰蛋白酶及胰凝乳蛋白酶的抑制作用。
Comp Biochem Physiol B. 1978;61(3):347-50. doi: 10.1016/0305-0491(78)90135-9.
2
Inhibition spectra of the human pancreatic endopeptidases.人胰腺内肽酶的抑制谱
Am J Clin Nutr. 1975 Aug;28(8):823-30. doi: 10.1093/ajcn/28.8.823.
3
Comparative inhibition of trypsins from several species by soybean trypsin inhibitors.大豆胰蛋白酶抑制剂对几种物种胰蛋白酶的比较抑制作用。
J Nutr. 1983 Apr;113(4):800-4. doi: 10.1093/jn/113.4.800.
4
Inhibition of trypsins and chymotrypsins from different animal species: a comparative study.不同动物物种的胰蛋白酶和糜蛋白酶抑制作用：一项比较研究。
Comp Biochem Physiol B. 1985;82(2):375-8. doi: 10.1016/0305-0491(85)90256-1.
5
An evaluation of endogenous pancreatic enzyme levels after human islet isolation.人胰岛分离后内源性胰腺酶水平的评估。
Pancreas. 2003 Aug;27(2):167-73. doi: 10.1097/00006676-200308000-00010.
6
A kinetic analysis of the inhibition of rat and bovine trypsins by naturally occurring protease inhibitors.天然存在的蛋白酶抑制剂对大鼠和牛胰蛋白酶抑制作用的动力学分析。
Comp Biochem Physiol B. 1986;84(1):53-7. doi: 10.1016/0305-0491(86)90270-1.
7
Bovine pancreatic trypsin inhibitor and soybean Kunitz trypsin inhibitor: Differential effects on proteases and larval development of the soybean pest Anticarsia gemmatalis (Lepidoptera: Noctuidae).牛胰蛋白酶抑制剂和大豆胰蛋白酶抑制剂：对大豆害虫银纹夜蛾（鳞翅目：夜蛾科）蛋白酶和幼虫发育的差异影响。
Pestic Biochem Physiol. 2022 Oct;187:105188. doi: 10.1016/j.pestbp.2022.105188. Epub 2022 Aug 1.
8
Raw soy and purified proteinase inhibitors induce the appearance of inhibitor-resistant trypsin and chymotrypsin activities in Wistar rat duodenal juice.生大豆和纯化的蛋白酶抑制剂可诱导Wistar大鼠十二指肠液中出现抗抑制剂的胰蛋白酶和糜蛋白酶活性。
J Nutr. 1991 Apr;121(4):532-8. doi: 10.1093/jn/121.4.532.
9
Purification and some properties of a highly active inhibitor of trypsin and alpha-chymotrypsin from soybeans.大豆中一种高活性胰蛋白酶和α-糜蛋白酶抑制剂的纯化及某些性质
Biochim Biophys Acta. 1961 Dec 9;54:378-81. doi: 10.1016/0006-3002(61)90387-0.
10
Kinetics of the inactivation of human and bovine trypsins and chymotrypsins by alpha1-proteinase inhibitor and of their reactivation by alpha2-macroglobulin.α1-蛋白酶抑制剂对人及牛胰蛋白酶和胰凝乳蛋白酶的失活动力学以及α2-巨球蛋白对它们的再激活动力学。
Clin Chim Acta. 1977 Aug 1;78(3):371-80. doi: 10.1016/0009-8981(77)90070-5.
Zotero 插件