Pasterkamp G, Schoneveld A H, Hillen B, Banga J D, Haudenschild C C, Borst C
Heart Lung Institute, Utrecht University Hospital, The Netherlands.
Atherosclerosis. 1998 Mar;137(1):205-10. doi: 10.1016/s0021-9150(97)00255-4.
The atherosclerotic carotid artery is easily accessible for non-invasive duplex investigation. The aim of the present post mortem study was to examine whether plaque accumulation and luminal stenosis in the common carotid artery is representative for atherosclerotic plaque accumulation and luminal stenosis in other peripheral arteries. A total of 3765 cross-sections were obtained at regular intervals from 240 arteries (24 individuals). Five types of peripheral arteries were investigated: common carotid, femoral, common iliac, external iliac and renal arteries. In each cross-section, the lumen area, vessel area, plaque area and maximal plaque thickness was measured. For each location, the percentage luminal stenosis and relative plaque area was calculated. Relative plaque area was defined as the percentage of the vessel area which was occupied by plaque. Weak correlations (r=0.41-0.59) were observed between percentage relative plaque area or maximal plaque thickness in the common carotid artery and percentage relative plaque area in other peripheral arteries. Neither plaque accumulation nor luminal stenosis in the common carotid artery correlated with the percentage luminal stenosis in other peripheral arteries (P > 0.05). We conclude that plaque area in the common carotid artery is weakly correlated with plaque area and not correlated with luminal stenosis in other peripheral arteries.
动脉粥样硬化的颈动脉易于进行非侵入性双功超声检查。本尸检研究的目的是检验颈总动脉中的斑块积聚和管腔狭窄是否代表其他外周动脉中的动脉粥样硬化斑块积聚和管腔狭窄。从240条动脉（24名个体）中定期获取了总共3765个横截面。研究了五种外周动脉：颈总动脉、股动脉、髂总动脉、髂外动脉和肾动脉。在每个横截面中，测量管腔面积、血管面积、斑块面积和最大斑块厚度。对于每个部位，计算管腔狭窄百分比和相对斑块面积。相对斑块面积定义为斑块所占血管面积的百分比。观察到颈总动脉中相对斑块面积百分比或最大斑块厚度与其他外周动脉中相对斑块面积百分比之间存在弱相关性（r = 0.41 - 0.59）。颈总动脉中的斑块积聚和管腔狭窄均与其他外周动脉中的管腔狭窄百分比无关（P > 0.05）。我们得出结论，颈总动脉中的斑块面积与其他外周动脉中的斑块面积弱相关，与管腔狭窄无关。
