儿童和青少年中种族、年龄及性激素差异与血清瘦素浓度的关系。

Relation of race, age, and sex hormone differences to serum leptin concentrations in children and adolescents.

作者信息

Ambrosius W T, Compton J A, Bowsher R R, Pratt J H

机构信息

Department of Medicine, Indiana University School of Medicine, and the VA Medical Center Indianapolis, USA.

出版信息

Horm Res. 1998;49(5):240-6. doi: 10.1159/000023178.

DOI:10.1159/000023178

PMID:9568809

Abstract

We explored the effects of race, age, and sex hormones on the serum leptin concentrations in 203 white and 88 black children and adolescents (ages 9.3-20.5 years). A significant sex by race interaction on serum leptin levels (p = 0.0301) was observed with lower serum leptin concentrations, adjusted for subscapular thickness and age, in black boys than in white boys. Girls had serum leptin levels that were on average 2.15 times those of boys (p < 0.0001). There was an age by sex interaction (p < 0.0001) with serum leptin concentrations decreasing in boys but not in girls with age. A strongly inverse relationship of serum testosterone levels with serum leptin levels in boys (p = 0.0067) appeared to explain this effect of age. In conclusion, the serum leptin concentration is slightly lower in black boys. A higher testosterone level in boys appears to account for an age-related decline in serum leptin in boys and the overall lower levels in boys than in girls.

摘要

我们研究了种族、年龄和性激素对203名白人及88名黑人儿童和青少年（年龄在9.3至20.5岁之间）血清瘦素浓度的影响。观察到血清瘦素水平存在显著的种族与性别交互作用（p = 0.0301），在根据肩胛下厚度和年龄进行调整后，黑人男孩的血清瘦素浓度低于白人男孩。女孩的血清瘦素水平平均是男孩的2.15倍（p < 0.0001）。存在年龄与性别的交互作用（p < 0.0001），血清瘦素浓度在男孩中随年龄降低，而在女孩中则不然。男孩血清睾酮水平与血清瘦素水平呈强负相关（p = 0.0067），这似乎解释了年龄对血清瘦素的这种影响。总之，黑人男孩的血清瘦素浓度略低。男孩较高的睾酮水平似乎解释了男孩血清瘦素随年龄下降以及男孩总体血清瘦素水平低于女孩的现象。