腺苷在儿童室上性心动过速治疗中的应用

Adenosine in the management of supraventricular tachycardia in children.

作者信息

Sherwood M C, Lau K C, Sholler G F

机构信息

Adolph Basser Cardiac Institute, Royal Alexandra Hospital for Children, Westmead, New South Wales, Australia.

出版信息

J Paediatr Child Health. 1998 Feb;34(1):53-6. doi: 10.1046/j.1440-1754.1998.00153.x.

DOI:10.1046/j.1440-1754.1998.00153.x

PMID:9568942

Abstract

OBJECTIVE

To assess the efficacy and safety of adenosine in the management of supraventricular tachycardia in children.

METHODOLOGY

A review of 43 children with supraventricular tachycardia who received intravenous adenosine between June 1992 and July 1995.

RESULTS

Thirty-five patients had re-entrant supraventricular tachycardia and eight patients had atrial tachydysrhythmias. Reversion to sinus rhythm occurred in 75% of episodes in all patients treated for supraventricular tachycardia, and in 96% of episodes in patients with re-entrant supraventricular tachycardia. Early re-initiation of supraventricular tachycardia after reversion to sinus rhythm occurred in 25% of episodes. Sixteen percent of patients reverted with the recommended 0.05 mg/kg starting dose, and 35% reverted with a dose of 0.1 mg/kg. Four patients were given adenosine as a diagnostic procedure to elicit occult pre-excitation. The most common side effects were brief feelings of discomfort. No serious side effects occurred.

CONCLUSION

Adenosine is safe and effective in the management of supraventricular tachycardia in children. A commencing dose of 0.1 mg/kg is appropriate.

摘要

目的

评估腺苷治疗儿童室上性心动过速的疗效和安全性。

方法

回顾1992年6月至1995年7月期间接受静脉注射腺苷治疗的43例儿童室上性心动过速患者。

结果

35例患者为折返性室上性心动过速，8例患者为房性快速心律失常。所有接受室上性心动过速治疗的患者中，75%的发作转为窦性心律，折返性室上性心动过速患者中96%的发作转为窦性心律。转为窦性心律后，25%的发作早期再次出现室上性心动过速。16%的患者使用推荐的0.05mg/kg起始剂量后转为窦性心律，35%的患者使用0.1mg/kg剂量后转为窦性心律。4例患者接受腺苷作为诊断程序以诱发隐匿性预激。最常见的副作用是短暂的不适感。未发生严重副作用。