新型杂环化合物6H-嘧啶并[2,1-a]异吲哚衍生物的抗真菌作用
Antifungal effects of new heterocyclic compounds, 6H-pyrimido[2,1-a]isoindole derivatives.
作者信息
Nesmĕrák K, Pelouchová H, Vsetecka V, Nĕmec I, Gabriel J
机构信息
Faculty of Science, Charles University, Prague, Czech Republic.
出版信息
Folia Microbiol (Praha). 1998;43(1):39-41. doi: 10.1007/BF02815539.
Minimal inhibitory concentrations for 10 new condensed isoindole derivatives were established by the agar diffusion method. Benzo[b]-6H-pyrimido[2,1-a]isoindole-4-one exhibited a broad antifungal effect; the observed MIC (mg/L) were 7 (K. lactis), 8 (C. pseudotropicalis), 17 (W. fluorescens), 22 (E. magnusii), 31 (P. membranaefaciens), 32 (S. alluvius) and 32 (S. cerevisiae). The compound also inhibited the growth of B. subtilis (MIC 9 mg/L). No effect on the growth of E. coli was found.
通过琼脂扩散法确定了10种新的稠合异吲哚衍生物的最低抑菌浓度。苯并[b]-6H-嘧啶并[2,1-a]异吲哚-4-酮表现出广泛的抗真菌作用；观察到的最低抑菌浓度（mg/L）分别为：7（乳酸克鲁维酵母）、8（近平滑假丝酵母）、17（荧光假单胞菌）、22（大埃希氏菌）、31（膜醭毕赤酵母）、32（冲积沙雷氏菌）和32（酿酒酵母）。该化合物还抑制枯草芽孢杆菌的生长（最低抑菌浓度9 mg/L）。未发现对大肠杆菌生长有影响。
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