Egyed M, Nyárádi A, Boros B, Viski A, Kelle M, Puskás A, Kocsis T, Horváth G
Kaposi Mór Megyei Kórház, Kaposvár, Belgyógyászati Osztály.
Orv Hetil. 1998 Apr 5;139(14):811-2.
A 44-year-old female patient was admitted to our department with diagnosis of malignant lymphoma. The abdominal USG and CT showed multiple liver lesions with partial portal vein thrombosis, moderately increased alfa-fetoprotein (AFP), ASAT, ALAT (2x normal value), serology was negative for HBV and HCV. Liver transplantation was suggested but refused because of portal vein thrombosis. ATRA (45 mg/m2/day orally) was given on the basis of the assumption that HCC and acute promyelocytic leukaemia share similar oncogenic pathway (alter the RAR alpha and beta receptors). She was gained 15 kg-s and has resumed her work as a teacher for the last 20 months. Abdominal CT showed a complete regression of the intrahepatic tumour.
一名44岁女性患者因恶性淋巴瘤诊断入院。腹部超声和CT显示肝脏有多个病灶并伴有部分门静脉血栓形成，甲胎蛋白（AFP）、谷草转氨酶（ASAT）、谷丙转氨酶（ALAT）中度升高（为正常值的2倍），乙肝病毒（HBV）和丙肝病毒（HCV）血清学检查均为阴性。曾建议进行肝移植，但因门静脉血栓形成而被拒绝。基于肝细胞癌（HCC）和急性早幼粒细胞白血病具有相似致癌途径（改变维甲酸受体α和β）这一假设，给予全反式维甲酸（ATRA，45mg/m²/天口服）治疗。她体重增加了15千克，在过去20个月里已恢复教师工作。腹部CT显示肝内肿瘤完全消退。
