Ogan A, Ozbayrak S
Department of Chemistry, Faculty of Arts and Sciences, Marmara University, Istanbul, Türkiye.
J Marmara Univ Dent Fac. 1996 Sep;2(2-3):520-2.
Recurrent oral ulcer (ROU) is a common disease whose the etiologic factors have not yet been identified. Although the autoimmune mechanism due to streptococcal antigens may be involved in this disease, serum immunoglobulins are reported to be higher than normal controls in various phases of ROU. Oral ulcers are one of the criteria in the diagnosis of some systemic diseases such as Wegener's granulomatosis, Behçet's syndrome, suppurative arthritis, Reiter's syndrome and neutropenias. Any patient with recurring oral ulcers should be evaluated medically for the possible presence or future development of serious systemic diseases. In this study of the 58% of the ROU patients who had positive ASO values, only one female patient had a moderate increase: ++ASO(= 400 IU), the rest had a slight increase: +ASO(= 200 IU). In the control group only 3 female subjects had +ASO (= 200 IU). The aim of this study was to determine whether there is any relationship between ROU and rheumatoid arthritis. Patients with ROU were examined for antistreptolysin O, rheumatoid factor and C-reactive protein and compared to healthy controls.
复发性口腔溃疡（ROU）是一种常见疾病，其病因尚未明确。尽管由链球菌抗原引起的自身免疫机制可能与该疾病有关，但据报道，在ROU的各个阶段，血清免疫球蛋白均高于正常对照组。口腔溃疡是某些全身性疾病（如韦格纳肉芽肿、白塞病、化脓性关节炎、赖特综合征和中性粒细胞减少症）诊断标准之一。任何患有复发性口腔溃疡的患者都应接受医学评估，以确定是否存在严重全身性疾病或其未来发展的可能性。在本研究中，58%的ROU患者抗链球菌溶血素O（ASO）值呈阳性，其中只有一名女性患者呈中度升高：++ASO（=400 IU），其余患者呈轻度升高：+ASO（=200 IU）。在对照组中，只有3名女性受试者的ASO为+（=200 IU）。本研究的目的是确定ROU与类风湿性关节炎之间是否存在任何关联。对ROU患者进行抗链球菌溶血素O、类风湿因子和C反应蛋白检测，并与健康对照组进行比较。
