Piao Z, Choi Y, Park C, Lee W J, Park J H, Kim H
Department of Pathology, Yonsei University College of Medicine, Seoul, South Korea.
Cancer Lett. 1997 Nov 25;120(1):39-43. doi: 10.1016/s0304-3835(97)00289-9.
To evaluate the different alteration patterns of the mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2r) gene in hepatocellular carcinoma (HCC), 41 HCCs were screened for homozygous deletion and loss of heterozygosity (LOH) at the M6P/IGF2r gene with a dinucleotide repeat polymorphic marker. Of these, three (8.8%) were heterozygous and LOH was observed in two (66.7%) of these informative cases. Five (14.7%) out of 34 informative cases showed homozygous deletions for the dinucleotide repeat polymorphic marker. The frequent allelic loss and homozygous deletion of the M6P/ IGF2r gene suggest that the M6P/IGF2r gene functions as a tumor suppressor gene in the development of HCC.
为评估肝细胞癌（HCC）中甘露糖6-磷酸/胰岛素样生长因子2受体（M6P/IGF2r）基因的不同改变模式，采用双核苷酸重复多态性标记对41例HCC进行M6P/IGF2r基因纯合缺失和杂合性缺失（LOH）筛查。其中，3例（8.8%）为杂合子，在这3例信息性病例中的2例（66.7%）观察到LOH。34例信息性病例中有5例（14.7%）显示双核苷酸重复多态性标记的纯合缺失。M6P/IGF2r基因频繁的等位基因缺失和纯合缺失表明，M6P/IGF2r基因在HCC发生发展中起肿瘤抑制基因的作用。
