Lüscher M S, Ravkilde J, Thygesen K
Department of Medicine and Cardiology, Aarhus University Hospital, Denmark.
Cardiology. 1998 Mar;89(3):222-8. doi: 10.1159/000006791.
The objective of this study was to determine whether two novel rapid bedside assays for whole-blood detection of cardiac troponin T and creatine kinase (CK)-MB mass/myoglobin could rule out or rule in acute myocardial infarction in patients with acute chest pain. Ninety-two patients with chest pain <12 h prior to admission were investigated. No difference in the cumulative sensitivity of the TropT test and the CARDIAC STATus test (CK-MB mass and myoglobin in combination) was found 6 h after admission (94 vs. 97%). The cumulative positive predictive value of the TropT test and CARDIAC STATus test 6 h after admission was 97 and 76%, respectively. The negative predictive value was 97% for the TropT test and 98% for the CARDIAC STATus test at this time point. Our data show that the rapid assays provide diagnostic as well as prognostic information shortly after admission.
本研究的目的是确定两种用于全血检测心肌肌钙蛋白T和肌酸激酶（CK）-MB质量/肌红蛋白的新型快速床边检测方法能否排除或确诊急性胸痛患者的急性心肌梗死。对92例入院前胸痛<12小时的患者进行了研究。入院6小时后，肌钙蛋白T检测和心脏状态检测（联合检测CK-MB质量和肌红蛋白）的累积敏感性无差异（分别为94%和97%）。入院6小时后，肌钙蛋白T检测和心脏状态检测的累积阳性预测值分别为97%和76%。此时，肌钙蛋白T检测的阴性预测值为97%，心脏状态检测的阴性预测值为98%。我们的数据表明，这些快速检测方法在入院后不久就能提供诊断和预后信息。
