Muriel P, Castro V
Departamento de Farmacología y Toxicología, Centro de Investigación y de Estudios, México DF, México.
J Appl Toxicol. 1998 Mar-Apr;18(2):143-7. doi: 10.1002/(sici)1099-1263(199803/04)18:2<143::aid-jat485>3.0.co;2-p.
Interferon-alpha2b (IFN) is known to prevent and to reverse experimental liver fibrosis and damage. S-Adenosyl-L-methionine (SAM) is a well-known hepatoprotective substance. The aim of the present work was to determine the effect of the administration of both drugs simultaneously to bile duct-ligated rats. Administration of IFN (50000 IU s.c.) and/or SAM (10 mg kg[-1] i.m.) began 15 days after biliary obstruction and continued for a further 15 days. The liver was used for glycogen and collagen quantification. Bilirubins and enzyme activities were measured in serum. Either SAM or IFN ameliorated all markers of liver damage studied. However, when administered together their beneficial effects were markedly reduced. It is not possible to explain the antagonistic effect of these compounds on liver damage with the present data. More studies are needed to determine SAM-IFN interactions.
已知α-2b干扰素（IFN）可预防并逆转实验性肝纤维化及肝损伤。S-腺苷-L-蛋氨酸（SAM）是一种广为人知的肝保护物质。本研究的目的是确定同时给予这两种药物对胆管结扎大鼠的影响。在胆管梗阻15天后开始给予IFN（50000 IU皮下注射）和/或SAM（10 mg kg[-1]肌肉注射），并持续15天。取肝脏进行糖原和胶原蛋白定量分析。测定血清中的胆红素和酶活性。单独使用SAM或IFN均可改善所研究的所有肝损伤指标。然而，当两者同时使用时，它们的有益作用明显降低。根据目前的数据尚无法解释这些化合物对肝损伤的拮抗作用。需要更多研究来确定SAM与IFN之间的相互作用。
