Carstensen J T, Lai T, Flickner D W, Huber H E, Zoglio M A
J Pharm Sci. 1976 Jul;65(7):992-7. doi: 10.1002/jps.2600650710.
The kinetics of wetting during the process of making tablet granulations were studied; the process progresses through an intermediate (overwetted) nonequilibrium granule to a final, equilibrated granule. In systematic formulation changes, there is an optimum composition from the point of view of hardness and content of equilibrium granules.
研究了片剂制粒过程中的润湿动力学；该过程通过中间（过度润湿）的非平衡颗粒发展到最终的平衡颗粒。在系统的配方变化中，从硬度和平衡颗粒含量的角度来看，存在一个最佳组成。
