豚鼠耳蜗螺旋神经节听觉神经元自发活动的分析。
Analysis of spontaneous activity of auditory neurones in the spiral ganglion of the guinea-pig cochlea.
作者信息
Manley G A, Robertson D
出版信息
J Physiol. 1976 Jun;258(2):323-36. doi: 10.1113/jphysiol.1976.sp011422.
Abstract
- Spontaneous activity of single afferent neurones in the cochlea of the guinea-pig was studied by measurement of mean rates and computation of interspike interval histograms. 2. The shapes of interval histograms agreed with those found in cat cochlear nerve fibres. Modes of the histograms were less than 7 msec for all cells with mean rates ranging from 20 to 150 spikes/sec. 3. The distribution of mean rates showed higher maximum rates than those found in cat. Cells from animals with abnormally high thresholds showed lower mean rates than those from sensitive animals. 4. No correlation was found between mean spontaneous rate and sensitivity to acoustic stimulation. No discrete populations of cells could be discerned on any of the criteria used. 5. The simultaneous effects of hypoxia on cell thresholds, mean spontaneous rate and scala media potentials are reported. These and other results are discussed in relation to possible sites of generation of spontaneous activity in primary auditory afferents.
摘要
- 通过测量平均发放率和计算峰峰间隔直方图，研究了豚鼠耳蜗单个传入神经元的自发放电活动。2. 间隔直方图的形状与猫耳蜗神经纤维中的形状一致。对于所有平均发放率在20至150次/秒之间的细胞，直方图的众数均小于7毫秒。3. 平均发放率的分布显示出比猫中更高的最大发放率。阈值异常高的动物的细胞平均发放率低于敏感动物的细胞。4. 未发现平均自发放电率与声刺激敏感性之间存在相关性。在使用的任何标准下都无法辨别出离散的细胞群体。5. 报告了缺氧对细胞阈值、平均自发放电率和中阶电位的同时影响。这些结果和其他结果结合初级听觉传入纤维中自发放电活动可能的产生部位进行了讨论。
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