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从人工耳蜗电描记术中噪声的频谱分析中获得的 3.1 kHz 频率峰值。

A frequency peak at 3.1 kHz obtained from the spectral analysis of the cochlear implant electrocochleography noise.

机构信息

Servicio Otorrinolaringología, Hospital Clínico de la Universidad de Chile, Santiago, Chile.

Departamento de Neurociencia, Facultad de Medicina, Universidad de Chile, Santiago, Chile.

出版信息

PLoS One. 2024 Mar 7;19(3):e0299911. doi: 10.1371/journal.pone.0299911. eCollection 2024.

DOI:10.1371/journal.pone.0299911
PMID:38451925
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10919660/
Abstract

INTRODUCTION

The functional evaluation of auditory-nerve activity in spontaneous conditions has remained elusive in humans. In animals, the frequency analysis of the round-window electrical noise recorded by means of electrocochleography yields a frequency peak at around 900 to 1000 Hz, which has been proposed to reflect auditory-nerve spontaneous activity. Here, we studied the spectral components of the electrical noise obtained from cochlear implant electrocochleography in humans.

METHODS

We recruited adult cochlear implant recipients from the Clinical Hospital of the Universidad de Chile, between the years 2021 and 2022. We used the AIM System from Advanced Bionics® to obtain single trial electrocochleography signals from the most apical electrode in cochlear implant users. We performed a protocol to study spontaneous activity and auditory responses to 0.5 and 2 kHz tones.

RESULTS

Twenty subjects including 12 females, with a mean age of 57.9 ± 12.6 years (range between 36 and 78 years) were recruited. The electrical noise of the single trial cochlear implant electrocochleography signal yielded a reliable peak at 3.1 kHz in 55% of the cases (11 out of 20 subjects), while an oscillatory pattern that masked the spectrum was observed in seven cases. In the other two cases, the single-trial noise was not classifiable. Auditory stimulation at 0.5 kHz and 2.0 kHz did not change the amplitude of the 3.1 kHz frequency peak.

CONCLUSION

We found two main types of noise patterns in the frequency analysis of the single-trial noise from cochlear implant electrocochleography, including a peak at 3.1 kHz that might reflect auditory-nerve spontaneous activity, while the oscillatory pattern probably corresponds to an artifact.

摘要

引言

在人类中，自发状态下听神经活动的功能评估仍然难以捉摸。在动物中，通过电测听记录的圆窗电噪声的频率分析在大约 900 到 1000 Hz 处产生一个频率峰，该频率峰被认为反映了听神经的自发活动。在这里，我们研究了人类耳蜗植入电测听获得的电噪声的频谱成分。

方法

我们从 2021 年至 2022 年期间招募了智利大学临床医院的成年耳蜗植入患者。我们使用 Advanced Bionics®的 AIM 系统从耳蜗植入使用者的最顶端电极获得单次试验电测听信号。我们进行了一项方案来研究自发活动以及对 0.5 和 2 kHz 音的听觉反应。

结果

共招募了 20 名受试者，其中包括 12 名女性，平均年龄为 57.9 ± 12.6 岁（36 至 78 岁）。在 55%的情况下（20 名受试者中的 11 名），单次试验耳蜗植入电测听信号的电噪声产生了一个可靠的 3.1 kHz 峰值，而在 7 名患者中观察到了掩盖频谱的振荡模式。在另外两个案例中，单次试验噪声无法分类。0.5 kHz 和 2.0 kHz 的听觉刺激并未改变 3.1 kHz 频率峰值的幅度。

结论

我们在耳蜗植入电测听的单次试验噪声的频率分析中发现了两种主要的噪声模式，包括 3.1 kHz 处的峰值，可能反映了听神经的自发活动，而振荡模式可能对应于一种伪影。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6beb/10919660/5b8806f166a1/pone.0299911.g011.jpg
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