Pritchard D I, Hewitt C, Moqbel R
Centre for the Mechanisms of Human Toxicity, Leicester, UK.
Parasitology. 1997;115 Suppl:S33-44. doi: 10.1017/s0031182097001996.
It should have been difficult until relatively recently for immunologists to ascribe a sound biological reason for the continued possession of the allergic phenotype in human populations. Nevertheless, for the past 20 years or so textbooks of immunology have routinely exhibited fanciful and perhaps exaggerated diagrams as to how IgE and eosinophils killed all helminth parasites. These diagrams were largely based on perhaps selective in vitro observations, and it is only now that immunoparasitologists, working on human populations under arduous conditions in the field, are able to provide data to corroborate these findings, and perhaps ascribe a useful purpose for a generally pathological immune response termed Type I hypersensitivity. The present paper reviews much of this recent literature, and asks a number of pertinent questions relating to the relationship between what we now know to be T-helper 2 lymphocyte-driven immunological responsiveness and infections with parasitic helminths.
直到最近，免疫学家要为人类群体中持续存在的过敏表型找到合理的生物学原因都应该是困难的。然而，在过去20年左右的时间里，免疫学教科书经常展示一些异想天开甚至可能夸大的图表，说明IgE和嗜酸性粒细胞是如何杀死所有蠕虫寄生虫的。这些图表很大程度上可能基于选择性的体外观察结果，直到现在，在艰苦的野外条件下研究人类群体的免疫寄生虫学家才能够提供数据来证实这些发现，并可能为一种被称为I型超敏反应的普遍病理性免疫反应赋予一个有用的目的。本文回顾了许多近期文献，并提出了一些与我们现在所知的由辅助性T2淋巴细胞驱动的免疫反应性和蠕虫寄生虫感染之间的关系相关的恰当问题。
