Holzgreve W, Ghezzi F, Di Naro E, Gänshirt D, Maymon E, Hahn S
Department of Obstetrics and Gynecology, University of Basel, Switzerland.
Obstet Gynecol. 1998 May;91(5 Pt 1):669-72. doi: 10.1016/s0029-7844(98)00068-4.
To investigate whether the transfer of fetal blood cells to the maternal circulation is perturbed in pregnancies affected by preeclampsia.
Fetal erythroblasts were isolated from eight women with clinically diagnosed preeclampsia (blood pressure values of at least 140/90 mmHg and associated proteinuria) and an equal number of matched corresponding controls. All patients in both groups were pregnant with male singleton fetuses. The presence of fetal cells was evaluated histologically and by fluorescence in situ hybridization for X and Y chromosomes.
The number of fetal cells was higher in preeclamptic patients than in controls, with respect to both nucleated red blood cells (median per 200 cells 38 versus 7; P < .001) and the proportion of these cells that were of fetal origin (median per 2000 cells 9 versus 2; P = .001).
These results suggest that the trafficking of fetal cells into the maternal periphery is disturbed in patients with preeclampsia. Because it is unlikely that such an altered flow of cells is restricted to the erythroblasts examined in this study, these findings also may lead to interesting new concepts regarding the development of preeclampsia and possibly the associated syndrome of hemolysis, elevated liver enzymes, and low platelets.
研究子痫前期孕妇中胎儿血细胞向母体循环的转移是否受到干扰。
从8例临床诊断为子痫前期（血压值至少为140/90 mmHg且伴有蛋白尿）的孕妇及相同数量的匹配对照中分离胎儿成红细胞。两组所有患者均怀有男性单胎胎儿。通过组织学检查以及对X和Y染色体进行荧光原位杂交来评估胎儿细胞的存在情况。
子痫前期患者的胎儿细胞数量高于对照组，无论是有核红细胞（每200个细胞中位数分别为38和7；P <.001）还是这些细胞中胎儿来源的比例（每2000个细胞中位数分别为9和2；P =.001）。
这些结果表明子痫前期患者中胎儿细胞向母体外周的转运受到干扰。由于这种细胞流动的改变不太可能仅限于本研究中检测的成红细胞，这些发现也可能会引发关于子痫前期以及可能相关的溶血、肝酶升高和血小板减少综合征发展的有趣新概念。
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