Osaki Y, Nishino I, Murakami N, Matsubayashi K, Tsuda K, Yokoyama Y I, Morita M, Onishi S, Goto Y I, Nonaka I
Department of Medicine and Geriatrics, Kochi Medical School, Nankoku-city, Kochi, Japan.
Muscle Nerve. 1998 May;21(5):637-9. doi: 10.1002/(sici)1097-4598(199805)21:5<637::aid-mus10>3.0.co;2-s.
We report a man who developed selenium-deficient myopathy during long-term parenteral nutrition. Muscle biopsy showed marked mitochondrial depletion in the deep sarcoplasm and enlarged mitochondria at the periphery mainly in type 2 fibers. Muscle weakness improved gradually after the second course of selenium supplementation. The peculiar mitochondrial abnormalities in muscle fibers appear to play a key role in the pathogenesis of selenium-deficient myopathy.
我们报告了一名在长期肠外营养期间发生硒缺乏性肌病的男性。肌肉活检显示，深层肌浆中线粒体明显减少，周边线粒体增大，主要见于2型纤维。在第二个疗程补充硒后，肌肉无力逐渐改善。肌纤维中特殊的线粒体异常似乎在硒缺乏性肌病的发病机制中起关键作用。
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