Cohen B H, Diamond E L, Graves C G, Kreiss P, Levy D A, Menkes H A, Permutt S, Quaskey S, Tockman M S
Department of Epidemiology, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland.
Lancet. 1977 Sep 10;2(8037):523-6. doi: 10.1016/s0140-6736(77)90663-8.
First-degree relatives of lung-cancer patients and of patients with chronic obstructive pulmonary disease had significantly higher age-sex-race-smoking-adjusted rates of impaired forced expiration than first-degree relatives of patients with non-pulmonary disease or community-derived comparison series (neighbourhood controls and teachers). Subclassification of the data and multiple adjustment for smoking, race, sex, and other confounding factors emphasised the consistency of the pattern. These findings strongly suggest that lung cancer and chronic obstructive pulmonary disease share a common familial component other than smoking. The clinical manifestation may depend on the presence of one or more other cofactors as yet undefined.
