Franco L, Najvar L, Gomez B L, Restrepo S, Graybill J R, Restrepo A
Corporacion para Investigaciones Biologicas, Medellin, Colombia.
Am J Trop Med Hyg. 1998 Apr;58(4):424-30. doi: 10.4269/ajtmh.1998.58.424.
Pulmonary fibrosis was induced following inoculation of Paracoccidioides brasiliensis conidia intranasally in BALB/c mice. Fibrosis was associated with formation of granulomas, increase in lung hydroxyproline, and sustained increases in tissue tumor necrosis factor-alpha and transforming growth factor-beta. This study suggests a role for these cytokines in generation of pulmonary fibrosis associated with chronic granulomatous infectious diseases.
通过经鼻接种巴西副球孢子菌分生孢子在BALB/c小鼠中诱导肺纤维化。纤维化与肉芽肿形成、肺羟脯氨酸增加以及组织肿瘤坏死因子-α和转化生长因子-β持续增加有关。本研究表明这些细胞因子在与慢性肉芽肿性传染病相关的肺纤维化形成中起作用。
