Buck A, Frey L D, Bläuenstein P, Krämer G, Siegel A, Weber B, Schubiger P A, Wieser H G
Division of Nuclear Medicine, University Hospital Zurich, Switzerland.
Eur J Nucl Med. 1998 May;25(5):464-70. doi: 10.1007/s002590050245.
Imaging of monoamine oxidase of subtype B (MAO B) is of interest in various neurological diseases. In the past non-invasive assessment of MAO B has only been possible with positron emission tomography (PET) ligands. Given the limited availability of PET, a single-photon emission tomography (SPET) ligand would be desirable. In this study SPET imaging with the new MAO B inhibitor [123I]Ro 43-0463 was performed in five volunteers and nine patients with temporal lobe epilepsy (TLE). In two volunteers a second study was performed 12 h following blockade with deprenyl. In the TLE patients the tracer was administered as bolus (n = 4) or as prolonged infusion (n = 5). The regional uptake pattern correlated well with the known distribution of MAO B. In the two blocking studies ligand uptake was substantially reduced compared with baseline. In the TLE patients increased uptake was found in the ipsilateral mesial temporal lobe and, surprisingly, in the ipsilateral putamen. This study indicates the potential of the new SPET ligand [123I]Ro 43-0463 to map MAO B concentration in the human brain. The new finding of increased MAO B in the putamen of TLE patients needs further studies to elucidate its exact pathophysiology.
B型单胺氧化酶（MAO B）成像在多种神经系统疾病中备受关注。过去，MAO B的非侵入性评估只能通过正电子发射断层扫描（PET）配体来实现。鉴于PET的可用性有限，单光子发射断层扫描（SPET）配体将是理想之选。在本研究中，使用新型MAO B抑制剂[123I]Ro 43 - 0463对5名志愿者和9名颞叶癫痫（TLE）患者进行了SPET成像。在两名志愿者中，在使用司来吉兰阻断12小时后进行了第二次研究。在TLE患者中，示踪剂以推注方式给药（n = 4）或长时间输注方式给药（n = 5）。区域摄取模式与已知的MAO B分布密切相关。在两项阻断研究中，与基线相比，配体摄取显著降低。在TLE患者中，发现同侧内侧颞叶以及令人惊讶的同侧壳核摄取增加。本研究表明新型SPET配体[123I]Ro 43 - 0463在绘制人脑MAO B浓度方面的潜力。TLE患者壳核中MAO B增加这一新发现需要进一步研究以阐明其确切的病理生理学。
