Kaliuzhnyĭ L V, Litvinova S V, Kaliuzhnyĭ A L, Aristova V V, Gruden' M A, Kozlov A Iu, Torgovanova G V, Fedoseeva O V
Department of Higher Nervous Activity, Lomonsov Moscow State University, Russia.
Eksp Klin Farmakol. 1998 Jan-Feb;61(1):21-4.
It was found that the absence of the analgesic effect of morphine, as determined by the tail-flick test, in morphine-resistant and morphine-tolerant rats, as well as in naloxane blockade of morphine analgesia in morphine-sensitive rats was attended with a four- to eight-fold increase in morphine antibodies in the plasma, as determined by the ELISA method. It is suggested that a pharmacokinetic factor mediated through immune reactions of morphine antibodies formation is one of the mechanisms of such conditions.
通过甩尾试验发现，在吗啡耐受和吗啡抵抗的大鼠中，吗啡失去了镇痛作用，并且在对吗啡敏感的大鼠中，纳洛酮阻断吗啡镇痛时，用酶联免疫吸附测定法（ELISA）测定血浆中的吗啡抗体增加了4至8倍。有人提出，由吗啡抗体形成的免疫反应介导的药代动力学因素是导致这种情况的机制之一。
